Mucosal Vaccination Against Encapsulated Respiratory Bacteria - New Potentials for Conjugate Vaccines?
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چکیده
منابع مشابه
Vaccination against encapsulated bacteria in humans: paradoxes.
Infection with encapsulated bacteria can be prevented by vaccination with capsular polysaccharides, either plain or conjugated to a protein carrier. But results concerning these vaccinations raise several paradoxes. Polysaccharides from encapsulated bacteria are generally considered to be T-independent antigens unable to trigger a T-dependent germinal center reaction, but strikingly, anti-polys...
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1Department of Health Sciences, School of Medical and Pharmaceutical Sciences, Postgraduate School in Occupational Medicine, University of Genoa and Medical Surveillance Unit for Health Care Workers, Occupational Medicine Unit, IRCCS San Martino Hospital, Largo R. Benzi 10, 16132 Genoa, Italy 2NIHRWellcome Trust Clinical Research Facility, University of Southampton, C Level, West Wing, Mailpoin...
متن کاملNeonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines
Encapsulated bacteria are responsible for the majority of mortality among neonates and infants. The major components on the surface of these bacteria are polysaccharides which are important virulence factors. Immunity against these components protects against disease. However, most of the polysaccharides are thymus-independent (TI)-2 antigens which induce an inadequate immune response in neonat...
متن کاملMucosal immune responses to meningococcal conjugate polysaccharide vaccines in infants.
BACKGROUND Serogroup C meningococcal conjugate polysaccharide vaccines have been reported to induce significant serum IgG antibodies and immunologic memory in infants. Because meningococcus is a mucosal pathogen colonizing the nasopharynx, local mucosal immune responses may play an important role in host defense against infection and carriage. We have investigated the mucosal IgA and IgG antibo...
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Needle-free, mucosal immunization is a highly desirable strategy for vaccination against many pathogens, especially those entering through the respiratory mucosa, such as Mycobacterium tuberculosis. Unfortunately, mucosal vaccination against tuberculosis (TB) is impeded by a lack of suitable adjuvants and/or delivery platforms that could induce a protective immune response in humans. Here, we r...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2003
ISSN: 0300-9475,1365-3083
DOI: 10.1046/j.1365-3083.2003.01292.x